A DISTAL INTERGENIC REGION CONTROLS PANCREATIC ENDOCRINE DIFFERENTIATION BY ACTING AS A TRANSCRIPTIONAL ENHANCER AND AS A POLYCOMB RESPONSE ELEMENT.

A distal intergenic region controls pancreatic endocrine differentiation by acting as a transcriptional enhancer and as a polycomb response element.

Lineage-selective expression of developmental genes is dependent on the Organza interplay between activating and repressive mechanisms.Gene activation is dependent on cell-specific transcription factors that recognize transcriptional enhancer sequences.Gene repression often depends on the recruitment of Polycomb group (PcG) proteins, although the s

read more


An Untargeted Metabolomic Analysis of Lacticaseibacillus (L.) rhamnosus, Lactobacillus (L.) acidophilus, Lactiplantibacillus (L.) plantarum and Limosilactobacillus (L.) reuteri Reveals an Upregulated Production of Inosine from L. rhamnosus

Lactic acid bacteria are considered an inexhaustible source of bioactive compounds; indeed, products from their metabolism are known to have immunomodulatory and anti-inflammatory activity.Recently, we demonstrated that Cell-Free Supernatants (CFS) obtained from Lactobacillus (L.) acidophilus, Lactiplantibacillus (L.) plantarum, Lacticaseibacillus

read more

FACILITATING THE FUNDING FOR THE CONSERVATION THROUGH TRADEABLE DEVELOPMENT RIGHTS: AN APPROACH THROUGH MAPPING AND ANALYZING THE BUILT HERITAGE AT AHMEDABAD, INDIA

In India, most of the built heritage is still retained by private ownership, who usually are un inproficient to provide the monetary support for the upkeep of the building.In such a scenario, the property goes into tracer pellets deterioration and is gradually lost.In response to this, the Ahmedabad Urban Develepment Authority (AUDA) have introduce

read more

Protective effects of S-allyl cysteine on behavioral, morphological and biochemical alterations in rats subjected to chronic restraint stress: Antioxidant and anxiolytic effects

S-allyl cysteine (SAC) is a garlic-derived compound with antioxidant properties.Restraint stress constitutes a rodent model mimicking different features of human stress.The effects of SAC on behavioral, biochemical and morphological endpoints of brain alterations induced by chronic restraint stress were evaluated in rats.Restraint stress sessions w

read more